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Related Experiment Videos

Single-scan quantitative T2* methods with susceptibility artifact reduction.

Florence Franconi1, Pierre Mowat, Laurent Lemaire

  • 1Service Commun d'Analyses Spectroscopiques, UFR Sciences, 2 boulevard Lavoisier, 49045 Angers cedex, France. florence.franconi@univ-angers.fr

NMR in Biomedicine
|April 7, 2006
PubMed
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Two new imaging methods, Multiple echo SubSlice AVEraging imaging (MSSAVE) and Multiple echo Gradient-Echo Slice-Excitation Profile Imaging (MGESEPI), were evaluated for quantitative T(2)* imaging. MGESEPI provided superior artifact reduction but required longer scan times compared to MSSAVE.

Area of Science:

  • Magnetic Resonance Imaging
  • Quantitative Imaging
  • Biomedical Engineering

Background:

  • Quantitative T(2)* imaging is crucial for assessing tissue magnetic susceptibility.
  • Existing single-scan methods often struggle with susceptibility artifacts and acquisition speed.
  • There is a need for efficient and accurate single-scan T(2)* evaluation techniques.

Purpose of the Study:

  • To propose and evaluate two novel single-scan quantitative T(2)* imaging methods: MSSAVE and MGESEPI.
  • To compare their performance against existing methods regarding artifact reduction, speed, and quantitation quality.
  • To assess their utility in both in vitro and in vivo settings.

Main Methods:

  • Development of MSSAVE (Multiple echo SubSlice AVEraging imaging) based on sub-slice averaging.

Related Experiment Videos

  • Development of MGESEPI (Multiple echo Gradient-Echo Slice-Excitation Profile Imaging) using slice direction over-sampling.
  • Comparative analysis of MSSAVE, MGESEPI, and conventional methods (FLASH, z-shimmed) using in vitro and in vivo rat brain data.

    • Main Results:

    • MGESEPI produced high-quality T(2)* maps with minimal susceptibility artifacts.
    • MSSAVE demonstrated faster acquisition times but with compromised artifact compensation and T(2)* quantitation.
    • Both methods were evaluated for sensitivity, minimum performance time, artifact reduction, and T(2)* quantitation quality.

    Conclusions:

    • MGESEPI offers excellent artifact-free T(2)* mapping but is limited by its long acquisition duration.
    • MSSAVE provides a faster alternative for T(2)* evaluation, albeit with reduced accuracy and artifact control.
    • The choice between MSSAVE and MGESEPI depends on the specific balance required between speed and image quality in quantitative T(2)* applications.