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Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
[Study on immunorepressive mice model by gamma irradiation]
Ye-Peng Li1, Yan-Jun Li, Chun-Hui Han
1Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Objective:
To establish the immunorepressive mice model by irradiation.
Methods:
The 90 Kunming mice which the weight is from 30 to 34g were treated with 3Gy, 4Gy, 5Gy gamma irradiation, the delayed allergy testing, the serum haemolysin level testing, the phagocytosing functions testing and the NK cell activity testing were performed at 3th, 7th, 14th, 21th days after irradiation respectively.
Results And Conclusion:
(1) All 3Gy, 4Gy, 5Gy gamma irradiation can cause mice immunorepressivestate except the NK cell activity. (2) The time of comeback after irradiation is different from immunity items. The serum haemolysin level is most sensitivity in all, but it comeback most slowly after irradiation. The phagocytosing functions comeback most rapidly after irradiation. (3) It suggests that the irradiation immunorepressive mice model can be established using it in order to evaluate the enhanceing immune function, assisting irradiation hazard protection function and alleviating toxicity function of irradiation treatment and chemical treatment. (4) The NK cell activity is not suitably to immunorespressive by gamma irradiation.
