Related Experiment Video
Updated: Aug 9, 2026
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
[Effect of excessive iodine exposure on the serum TC and TG level in rats]
Xue-Feng Yang1, Hong Pang, Jian Xu
1Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Hua zhong University of Science and Technology, Wuhan 430030, China.
Objective:
To study effect of excessive iodine exposure on the serum TC and TG level in rate.
Methods:
According to body weight, 60 Wistar rats were divided into 6 groups and given drinking water including different doses of iodine. The iodine concentrations were 0 (control), 1800, 3600, 7200, 14000 and 28000 microg/L, respectively. Three months later, related indices were determined.
Results:
In excessive iodine groups, no obvious changes of thyroid morphology was observed. Urinary iodine level increased dose-dependently. Excessive iodine intake resulted in a significant reduce of serum TT4 level and an obvious increase of serum TC level in a dose-dependent manner. The positive correlation was observed between serum TC and urinary iodine. There was the negative correlation between serum TC and serum T4.
Conclusion:
Excessive-iodine exposure resulted in an increase in serum TC level. And serum lipids, together with urinary iodine and serum thyroid hormones, could be used as biomarkers for excessive iodine exposure.
