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Allergic bronchopulmonary aspergillosis.

Cecilia P Mikita¹, Jeffrey A Mikita

¹Department of Allergy and Immunology and Sleep Medicine Service, Walter Reed Army Medical Center, Washington DC 20307, USA. cecilia.mikita@amedd.army.mil

Allergy and Asthma Proceedings

|April 8, 2006

Summary

Allergic bronchopulmonary aspergillosis (ABPA) is an immune response to Aspergillus in the lungs, distinct from other fungal lung diseases. Corticosteroids are the primary treatment, proving effective for managing this condition.

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Area of Science:

Pulmonology
Allergy and Immunology
Mycology

Background:

Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to Aspergillus antigens.
It is a distinct clinical entity separate from invasive or saprophytic Aspergillus infections of the lung.
Understanding ABPA is crucial for allergists and pulmonologists managing complex respiratory conditions.

Observation:

Common manifestations include episodic bronchospasm, expectoration of mucus plugs, and transient pulmonary infiltrates.
ABPA presents as a unique hypersensitivity pneumonitis.
The condition requires careful differentiation from other pulmonary diseases.

Findings:

Diagnosis typically involves asthma and a positive skin prick test to Aspergillus fumigatus.

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Diagnostic criteria can vary, but core elements remain consistent.

Early and accurate diagnosis is key to effective management.

Implications:

Corticosteroids form the cornerstone of ABPA treatment and are generally effective.
Management strategies should focus on reducing inflammation and preventing lung damage.
Clinical pearls and pitfalls are essential for successful patient outcomes in ABPA.