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Published on: November 4, 2010
Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast
J Reyes-Balaguer1, D Hernández de Rojas
1Allergy Department. Hospital Universitario La Fe. Valencia, Spain. galima@ono.com
Abstract:
Asthmatic patients receiving antileukotrienes may develop hypereosinophilia as a part of a Churg-Strauss syndrome. It is unclear if this effect is directly related to the administration of antileukotrienes or a consequence of the corticosteroid-sparing effect of antileukotrienes unmasking a Churg-Strauss syndrome. We present a case of hypereosinophilia related to zafirlukast therapy. The patient did not fulfil criteria for Churg-Strauss syndrome. Symptoms and laboratory findings improved after zafirlukast was removed.
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