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Updated: Aug 9, 2026
07:15
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
Synovial sarcoma of the heart
Sylvio Carvalho Provenzano1, Richard Con, Owen D Jones
1Department of Cardiothoracic Surgery, Royal Perth Hospital, Wellington Street, Perth, WA 6000, Australia. sylvioprovenzano@hotmail.com
Heart, Lung & Circulation
|April 8, 2006
Summary
A rare cardiac synovial sarcoma in a 14-year-old boy led to rapid hemodynamic collapse. Despite incomplete resection, the patient remained asymptomatic after 18 months of chemotherapy.
Area of Science:
- Cardiovascular Pathology
- Pediatric Oncology
- Surgical Oncology
Background:
- Synovial sarcoma, a rare soft tissue malignancy, can occur in the heart.
- Cardiac tumors in pediatric patients are uncommon and present diagnostic challenges.
Observation:
- A 14-year-old boy presented with generalized illness and rapid hemodynamic compromise.
- A tumor was identified attached to the tricuspid valve, near the atrioventricular junction.
- Incomplete tumor resection was noted due to extensive adhesions.
Findings:
- The patient received chemotherapy following surgical intervention.
- Post-treatment follow-up at 18 months showed the patient to be asymptomatic.
- This case highlights the potential for favorable outcomes despite challenging surgical circumstances.
Implications:
- Early diagnosis and multimodal treatment are crucial for managing cardiac synovial sarcoma.
- Further research into the long-term prognosis and optimal treatment strategies for pediatric cardiac tumors is warranted.
- This case contributes to the understanding of rare cardiac malignancies and their management in adolescents.
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