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Related Experiment Videos

Risperidone and adaptive behavior in children with autism.

Susan K Williams1, Lawrence Scahill, Benedetto Vitiello

  • 1Yale University, New Haven, CT 06520-7900, USA.

Journal of the American Academy of Child and Adolescent Psychiatry
|April 8, 2006
PubMed
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Risperidone treatment significantly improved adaptive behaviors in children with autistic disorder and serious behavioral problems. The medication enhanced skills in communication, daily living, and socialization over a 6-month period.

Area of Science:

  • Child Psychiatry
  • Neurodevelopmental Disorders
  • Pharmacological Interventions

Background:

  • Autistic disorder often presents with serious behavioral problems.
  • Adaptive behavior is crucial for daily functioning in children.
  • Limited data exists on pharmacological interventions for adaptive behavior in this population.

Purpose of the Study:

  • To evaluate risperidone's impact on adaptive behavior in children with autistic disorder and severe behavioral issues.
  • To assess the utility of different scoring methods of the Vineland Adaptive Behavior Scales for measuring treatment-related changes.

Main Methods:

  • A 6-month follow-up study of 48 children (aged 5-16) with autistic disorder.
  • Children had previously shown behavioral improvement with risperidone.

Related Experiment Videos

  • Adaptive behavior was assessed using the Vineland Adaptive Behavior Scales.

    • Main Results:

    • Significant improvements were observed in communication, daily living skills, and socialization (p <.01).
    • Children gained an average of 7.8 age-equivalent months in socialization over 6-8 months.
    • This represents a >6% improvement beyond expected growth rates.

    Conclusions:

    • Risperidone may enhance adaptive skills in children with autistic disorder and serious behavioral problems.
    • The study was limited by the absence of a control group.
    • Vineland age-equivalent scores are recommended for assessing treatment-induced changes over time.