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Prothrombotic activity is associated with the anatomical as well as the functional severity of peripheral arterial

Marthe Nylaende1, Andries Kroese, Einar Stranden

  • 1Department of Vascular Surgery, Aker University Hospital, Oslo, Norway. marthe@nylaende.com

Thrombosis and Haemostasis
|April 8, 2006
PubMed

Insights

Prothrombotic activity, indicated by D-dimer, TAT, and fibrinogen levels, is linked to the severity of peripheral arterial occlusive disease (PAD). These markers predict atherosclerosis extent and may aid future PAD diagnosis and treatment.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Vascular Biology

Background:

  • Prothrombotic activity is crucial in cardiovascular disease.
  • Limited data exist on its association with peripheral arterial occlusive disease (PAD) severity.
  • Investigating hemostatic markers in PAD is essential.

Purpose of the Study:

  • To explore the relationship between hemostatic markers and PAD severity.
  • To assess correlations with ankle-brachial index (ABI), walking distance, and angiographic scores.
  • To identify predictors of atherosclerosis in PAD patients.

Main Methods:

  • Cross-sectional study of 127 patients with angiographically verified PAD.
  • Measurement of hemostatic variables: vWF, sTM, TAT, sTF, tPAag, and D-dimer.
  • Correlation analysis with ABI, maximum treadmill walking distance, and angiographic score.

Main Results:

  • Hemostatic markers (D-dimer, TAT, fibrinogen) correlated with PAD severity measures.
  • D-dimer, tPAag, and fibrinogen inversely correlated with walking distance.
  • Fibrinogen uniquely correlated with ABI and predicted both walking distance and ABI independently.

Conclusions:

  • Plasma levels of D-dimer, TAT, and fibrinogen significantly predict PAD extent.
  • Findings suggest a prothrombotic state in PAD patients.
  • These markers may be important for future PAD diagnosis and treatment strategies.

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