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Updated: Aug 9, 2026
10:46
Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models
Published on: May 3, 2017
[Glutamate and Alzheimer's disease]
1Sección de Neurología, Hospital San Jorge, Huesca, Spain. josegazulla@wanadoo.es
Revista De Neurologia
|April 8, 2006
Summary
Glutamatergic dysfunction is important in Alzheimer's disease (AD) development. This neurotransmitter imbalance may be a secondary effect of other underlying genetic or metabolic changes in AD pathogenesis.
Area of Science:
- Neuroscience
- Biochemistry
Context:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
- Glutamatergic neurotransmission is a key excitatory pathway in the brain.
Purpose:
- To analyze the role of the neurotransmitter glutamate in Alzheimer's disease (AD) pathogenesis.
- To review glutamatergic system physiology and its alterations in AD.
Summary:
- Physiological glutamatergic neurotransmission involves specific neurons, receptors, and transporters.
- AD neuropathology shows altered brain glutamate levels, receptor, and transporter characteristics.
- Slow excitotoxicity, a mechanism linked to neurodegeneration, is analyzed in the context of AD.
Impact:
- Glutamatergic dysfunction is implicated in Alzheimer's disease pathogenesis.
- This dysfunction is likely secondary to other neurochemical, genetic, or metabolic factors driving AD development.
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