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Related Experiment Videos

Microelectrode array for chronic deep-brain microstimulation and recording.

Douglas McCreery1, Albert Lossinsky, Victor Pikov

  • 1Huntington Medical Research Institutes, Neural Engineering Program, 734 Fairmount Ave., Pasadena, CA 91105, USA. dougmc@hmri.org

IEEE Transactions on Bio-Medical Engineering
|April 11, 2006
PubMed
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Researchers developed a microelectrode array for long-term deep brain implantation to record single neurons and deliver microstimulation, aiding Parkinson's disease research and potential clinical tools.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Neurosurgery

Background:

  • Deep brain stimulation (DBS) shows promise for Parkinson's disease (PD) and movement disorders.
  • Understanding DBS mechanisms requires precise neural recording and stimulation.
  • Current tools may lack the specificity for targeted intranuclear interventions.

Purpose of the Study:

  • To develop and evaluate a novel microelectrode array for chronic implantation in deep brain structures.
  • To assess the array's capability for single-unit recording and localized microstimulation.
  • To investigate the potential of this technology for PD treatment and research.

Main Methods:

  • Fabrication of a 16-channel iridium microelectrode array (1.8 mm diameter) using USP Class VI materials.

Related Experiment Videos

  • Development of a surgical apparatus and procedure for deep brain implantation.
  • Chronic implantation (140-415 days) in feline subthalamic nucleus (STN) and globus pallidus.

    • Main Results:

    • Successful chronic implantation and recording of action potentials from 4-8 channels.
    • Demonstrated ability to deliver controlled microstimulation (26.5 µA, 150 µs/phase) to excite STN neurons.
    • Stimulation modulated neuronal activity up to 1.2 mm; no detectable histological changes with sufficient surface area after 35 hours of stimulation.

    Conclusions:

    • The developed microelectrode array is suitable for long-term implantation and functional recording/stimulation in deep brain nuclei.
    • This technology offers high spatial specificity for intranuclear microstimulation.
    • The array represents a potential basis for advanced clinical tools in treating movement disorders like Parkinson's disease.