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Related Experiment Videos

Intravenous magnesium.

E Connolly1, L I Worthley

  • 1Department of Critical Care Medicine, Flinders Medical Centre, Adelaide, SA Australia.

Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine
|April 11, 2006
PubMed
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Intravenous magnesium therapy is crucial for magnesium-depleted patients and beneficial for non-depleted individuals with various conditions. This review highlights magnesium

Area of Science:

  • Biochemistry
  • Pharmacology
  • Clinical Medicine

Background:

  • Magnesium is a vital cofactor in numerous enzymatic reactions, particularly those involving adenosine triphosphate (ATP).
  • Magnesium deficiency is linked to increased morbidity and mortality from cardiovascular, neurological, and metabolic disorders.
  • Therapeutic interventions with magnesium can rapidly correct these deficiencies.

Purpose of the Study:

  • To comprehensively review the established functions and clinical applications of intravenous magnesium.
  • To evaluate its efficacy in both magnesium-depleted and non-magnesium-depleted patient populations.
  • To explore its therapeutic potential across a spectrum of medical conditions.

Main Methods:

  • A systematic literature review was conducted.

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  • Studies published between 1966 and 1998 were identified via MEDLINE.
  • The search focused on English-language articles detailing intravenous magnesium use.

    • Main Results:

    • Intravenous magnesium administration can correct magnesium deficiency, improving associated cardiovascular, neurological, and metabolic symptoms.
    • Evidence suggests magnesium alters ion channels, NMDA receptors, and calcium metabolism.
    • Beneficial effects are observed in non-magnesium-depleted patients with various disorders, including cardiovascular conditions, respiratory issues, and metabolic imbalances.
    • Standard dosing involves an initial bolus of 8–16 mmol over 5 minutes, followed by a 2–4 mmol/h infusion to maintain plasma levels between 1.5–3 mmol/L.

    Conclusions:

    • Magnesium is essential for magnesium-depleted patients.
    • Intravenous magnesium offers therapeutic benefits for non-magnesium-depleted patients, particularly those with pre-eclampsia.
    • Potential benefits extend to non-magnesium-depleted patients experiencing acute coronary syndromes, arrhythmias, asthma, stroke, seizures, and spinal cord injuries.