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Related Experiment Videos

CED: a conformational epitope database.

Jian Huang1, Wataru Honda

  • 1Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. hjian@kuicr.kyoto-u.ac.jp

BMC Immunology
|April 11, 2006
PubMed
Summary
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A new database, CED, offers a curated collection of conformational epitopes, crucial for understanding disease prevention and diagnosis. This resource provides structural and immunological details, complementing existing databases for immunology research.

Area of Science:

  • Immunology
  • Bioinformatics
  • Structural Biology

Background:

  • Antigen epitopes are vital for disease prevention, diagnosis, and treatment.
  • Conformational epitopes, formed by spatially close but sequentially discontinuous residues, hold significant structural information.
  • Existing databases predominantly focus on linear epitopes, leaving a gap for conformational epitope data.

Purpose of the Study:

  • To develop and present CED, a specialized database for well-defined conformational epitopes.
  • To provide a centralized resource for researchers in theoretical and applied immunology.
  • To complement existing epitope databases with a focus on conformational epitopes.

Main Methods:

  • Manual curation of conformational epitope data from peer-reviewed literature.

Related Experiment Videos

  • Integration of epitope information including residue composition, location, immunological properties, source antigen, and antibody.
  • Development of a user-friendly web interface for browsing and searching the database.
  • Inclusion of interactive 3D structure visualization for epitopes.
  • Hyperlinking entries to external databases (Swiss-Prot, PDB, KEGG, PubMed) for comprehensive background information.

    • Main Results:

    • CED successfully compiles a collection of conformational epitopes with detailed associated information.
    • The database offers interactive visualization of epitope structures in 3D.
    • Entries are linked to external resources, providing extensive contextual data.
    • CED is accessible via a user-friendly web interface.

    Conclusions:

    • The Conformational Epitope Database (CED) has been established as a valuable information resource.
    • CED supports investigators in both theoretical and applied immunology research.
    • This database effectively complements other specialized epitope databases.