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Histamine H3 receptors: an overview.
G Bertaccini1, G Coruzzi, M Adami
1Istituto di Farmacologia, Ospedale Maggiore, Università di Parma, Italy.
The Italian Journal of Gastroenterology
|July 1, 1991
Summary
Histamine H3 receptors modulate neurotransmitter release in the brain and periphery. In the gastrointestinal tract, these receptors inhibit gastric acid secretion and motility.
Area of Science:
- Neuropharmacology
- Gastroenterology
Background:
- Histamine H3 receptors, initially identified in the central nervous system, modulate histamine synthesis and release.
- These receptors are now recognized in peripheral tissues, acting as autoreceptors on histaminergic neurons and heteroreceptors on other nerve endings.
Purpose of the Study:
- To investigate the role of Histamine H3 receptors in the gastrointestinal tract.
- To understand their function in regulating gastric acid secretion and motility.
Main Methods:
- Electrically stimulated isolated gastrointestinal preparations were used.
- The effects of Histamine H3 receptor agonists and antagonists were observed.
Main Results:
- Histamine H3 receptors appear to negatively control gastric acid secretion.
- They also negatively regulate gastrointestinal motility.
- Evidence suggests these receptors are not present in effector organs.
Conclusions:
- Histamine H3 receptors play a significant role in modulating gastrointestinal functions.
- Selective agonists like (R) alpha-methylhistamine and antagonists like thioperamide are valuable tools for further research.