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Effects of psoralen-UV-A-Turban in alopecia areata
Grazyna Broniarczyk-Dyla1, Anna Wawrzycka-Kaflik, Malgorzata Dubla-Berner
1Department of General, Esthetic Dermatology and Dermatosurgery, Medical University of Lodz, Poland. dylagrazyna@wp.pl
Background:
Psoralen-UV-A (PUVA)-turban is a modification of PUVA-bath therapy used in alopecia areata.
Objective:
The aim of this study was to assess the efficacy of PUVA-turban in different forms of alopecia areata. Twenty patients completed the study: nine with alopecia areata vulgaris and 11 with alopecia areata totalis or universalis.
Methods:
8-methoxypsoralen in a dilution of 0.0001% (1 mg/L) was administered to the scalp for 20 minutes using a cotton towel as a turban. The application was followed by UV-A radiation. Treatments were performed two or three times weekly. The cumulative doses ranged from 48.2-253.4 J/cm2, and single fractions ranged from 0.3-6.5 J/cm2.
Results:
Hair regrowth was observed in 15 patients (total regrowth in six patients and partial regrowth in nine patients). Five patients did not respond to the therapy.
Conclusions:
PUVA-turban was significantly more effective in alopecia areata vulgaris than in alopecia areata totalis or universalis and proved to be a safe, well tolerated method without the systemic side effects of PUVA.
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