Related Experiment Video
Updated: Aug 9, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
Nogo-66 receptor at the gap junctions between pituicytes of the rat
Ya-Zhou Wang1, Ying-Ying Liu, Jin-Ping Liu
1Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China.
Abstract:
Nogo-66 receptor was first identified in neurons. Recently, it was demonstrated in glial cells as well. Our previous study on the expression of Nogo-66 receptor in the cerebellum of the rat surprisingly found its location at the glial gap junctions. Here, we present our study on Nogo-66 receptor in the rat posterior pituitary, which is densely packed with pituicytes, a special type of astrocyte, and is known to be rich in gap junctions. We were able to demonstrate with immunohistochemistry and immuno-electron microscopy abundant Nogo-66 receptor immunoreactive gap junctions between pituicytes. This study, together with our prior one, strongly suggests that the Nogo-66 receptor may play a role in regulating the function of the gap junctions.
Related Concept Videos
Gap Junctions
Gap Junctions
G-protein Coupled Receptors
G-Protein Gated Ion Channels
Sensory organs,...
IP3/DAG Signaling Pathway

