Related Experiment Videos
Bovine lens capsule basement membrane collagen exerts a negative priming on polymorphonuclear neutrophils
J C Monboisse1, G Bellon, C Perreau
1Laboratoire de Biochimie, URA CNRS 610, Faculté de Médecine de l'Université de Reims, France.
FEBS Letters
|December 2, 1991
Abstract:
After a 30 min contact between purified bovine lens capsule basement membrane type IV collagen and polymorphonuclear neutrophils, stimulation of these cells by N-formyl-methionyl-leucyl-phenylalanine, PMA or type I collagen releases a decreased amount of superoxide ions (negative priming). The inhibitory activity is located in the NCl domain. On the other hand, after pepsin digestion, the helical part of type IV collagen determines a positive priming of neutrophils.