Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clickity-click: highly functionalized peptoid oligomers generated by sequential conjugation reactions on solid-phase

Justin M Holub1, Hangjun Jang, Kent Kirshenbaum

  • 1Department of Chemistry, New York University, New York, NY 10003, USA.

Organic & Biomolecular Chemistry
|April 11, 2006
PubMed
Summary

Researchers developed a new method for creating complex peptidomimetics using sequential azide-alkyne cycloaddition reactions. This technique enables precise placement of diverse functional groups, paving the way for novel biosensor development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>In Vivo</i> Activity of Antimicrobial Peptoid Oligomers against HSV-1 in a Mouse Model of Herpes Labialis.

ACS infectious diseases·2026
Same author

Quantitative holographic agglutination assay for immunoglobulin A.

Biomedical optics express·2026
Same author

Structural and Positional Effects of Peptoid Residues on Triple Helix Stability.

Biomacromolecules·2026
Same author

Native Chemical Ligation of Peptoid Oligomers.

Biochemistry·2026
Same author

A helical peptide antagonist of the human growth hormone receptor.

Endocrinology·2026
Same author

In Vivo Efficacy of a Macrocyclic Peptoid-Peptide Hybrid That Selectively Modulates the Beta-Catenin/TCF Interaction to Inhibit Prostate Cancer.

The Prostate·2025

Area of Science:

  • Chemical Synthesis
  • Materials Science
  • Biotechnology

Background:

  • N-substituted glycine peptoid oligomers offer unique structural properties.
  • Azide-alkyne cycloaddition is a powerful click chemistry tool for conjugation.
  • Site-specific functionalization is crucial for creating complex molecular architectures.

Purpose of the Study:

  • To develop a novel sequential conjugation technique for N-substituted glycine peptoid oligomers.
  • To demonstrate the ability to site-specifically position multiple heterogeneous pendant groups.
  • To explore the potential application of these conjugates in biosensor development.

Main Methods:

  • Utilizing N-substituted glycine peptoid oligomers as substrates.
  • Employing azide-alkyne [3+2] cycloaddition reactions for conjugation.

Related Experiment Videos

  • Implementing sequential rounds of oligomerization and cycloaddition.

    • Main Results:

    • Successful generation of complex peptidomimetic products.
    • Demonstrated site-specific positioning of multiple heterogeneous pendant groups.
    • Created a water-soluble estradiol-ferrocene peptoid conjugate.

    Conclusions:

    • The sequential conjugation technique is effective for synthesizing complex peptidomimetics.
    • This method allows for precise control over pendant group placement.
    • Peptoid conjugates show promise for modular biosensor synthesis.