Related Experiment Video
Updated: Aug 2, 2026

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
Published on: February 17, 2015
Entrainment of coupled oscillators on regular networks by pacemakers
Filippo Radicchi1, Hildegard Meyer-Ortmanns
1School of Engineering and Science, International University Bremen, P. O. Box 750561, D-28725 Bremen, Germany. f.radicchi@iu-bremen.de
Abstract:
We study Kuramoto oscillators, driven by one pacemaker, on d-dimensional regular topologies with nearest neighbor interactions. We derive the analytical expressions for the common frequency in the case of phase-locked motion and for the critical frequency of the pacemaker, placed at an arbitrary position in the lattice, so that above the critical frequency no phase-locked motion is possible. We show that the mere change in topology from an open chain to a ring induces synchronization for a certain range of pacemaker frequencies and couplings, while keeping the other parameters fixed. Moreover, we demonstrate numerically that the critical frequency of the pacemaker decreases as a power of the linear size of the lattice with an exponent equal to the dimension of the system. This leads in particular to the conclusion that for infinite-dimensional topologies the critical frequency for having entrainment decreases exponentially with increasing size of the system, or, more generally, with increasing depth of the network, that is, the average distance of the oscillators from the pacemaker.
Related Concept Videos
RLC Circuit as a Damped Oscillator
Consider a series RLC circuit. Here, the presence of resistance in the circuit leads to energy loss due to joule heating in the resistance. Therefore, the total electromagnetic energy in the circuit is no longer constant and decreases with time. Since the magnitude of charge, current, and potential difference continuously decreases, their oscillations are said to be damped. This is...
Muscle Stimulation Frequency
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Propagation of Action Potentials
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Electrophysiology of Normal Cardiac Rhythm
Mechanism of Cardiac Arrhythmias
Conduction System of the Heart
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...

