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Adenovirus infection in two calves
Journal of the American Veterinary Medical Association
|February 1, 1975
Summary
Two calves experienced severe illness, showing pyrexia and diarrhea. Necropsy revealed adenovirus particles in various tissues, indicating a significant viral infection in the young animals.
Area of Science:
- Veterinary Pathology
- Virology
- Bovine Medicine
Background:
- Calfhood diseases often present with gastrointestinal and systemic signs.
- Prompt diagnosis is crucial for effective disease management in livestock.
- Identifying causative agents aids in understanding disease pathogenesis.
Purpose of the Study:
- To identify the pathological cause of severe illness in two calves.
- To characterize the viral agent responsible for the observed lesions.
Main Methods:
- Clinical case presentation of two affected calves.
- Gross necropsy examination of abdominal organs.
- Histopathological examination of tissues, focusing on endothelial cells and identifying intranuclear inclusions.
Main Results:
- Calves presented with pyrexia, diarrhea, and dehydration unresponsive to symptomatic treatment.
- Necropsy revealed necrotic foci in the abomasum and rumen, with intestinal dilation.
- Intranuclear inclusions consistent with adenovirus particles were identified in endothelial cells of blood vessels (abomasum, rumen, adrenal glands, renal glomeruli) and intestinal epithelial cells.
Conclusions:
- Adenovirus infection was identified as the cause of severe illness and pathological changes in the calves.
- The findings highlight the potential for adenovirus to cause significant morbidity and mortality in young cattle.
- Intranuclear inclusions in endothelial cells serve as a key diagnostic marker for this adenovirus-induced pathology.