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Long-term performance of active-fixation pacing leads: a prospective study
Peter M Kistler1, Gary Liew, Harry G Mond
1Department of Cardiology, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia.
Pacing and Clinical Electrophysiology : PACE
|April 12, 2006
Summary
This study shows active-fixation pacing leads maintain stable parameters over two years. Pacing thresholds and sensing remain consistent, indicating reliable long-term performance.
Area of Science:
- Cardiology
- Biomedical Engineering
- Medical Device Technology
Background:
- Long-term clinical data on active-fixation pacing leads is limited.
- This study addresses the need for extended follow-up on pacing lead outcomes.
- Active-fixation leads are increasingly utilized in pacemaker implants.
Purpose of the Study:
- To analyze pacing parameters of active-fixation leads over a 2-year follow-up period.
- To assess the stability of pacing thresholds, sensing, and impedance.
- To evaluate the long-term clinical performance of specific active-fixation lead models.
Main Methods:
- Prospective observational study of 100 dual-chamber pacemaker implants.
- Utilized St. Jude 1488T and Medtronic 5076 active-fixation leads.
- Pacing parameters (threshold, R wave, impedance) measured at implant and at multiple intervals up to 24 months.
Main Results:
- Ventricular thresholds increased significantly from day 1 to month 1, then stabilized. A few cases exceeded 2V between days 1-3.
- Ventricular impedance significantly declined from day 1 to month 1, then remained stable. R wave sensing was stable.
- Atrial parameters, including threshold, sensing, and impedance, remained stable throughout the 2-year follow-up. No lead complications or repositioning needed.
Conclusions:
- Active-fixation leads demonstrate generally stable long-term pacing parameters.
- The study supports the reliability of active-fixation leads for extended pacemaker use.
- No major lead-related complications were observed during the 2-year follow-up.