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Perioperative intraperitoneal chemotherapy for peritoneal surface malignancy.

Tristan D Yan1, Oswald A Stuart, Dal Yoo

  • 1Peritoneal Surface Malignancy Program, Washington Cancer Institute, Washington, DC, USA. tristan.yan@unsw.edu.au

Journal of Translational Medicine
|April 12, 2006
PubMed
Summary

Cytoreductive surgery combined with intraperitoneal chemotherapy offers improved survival for peritoneal surface malignancy. This review details perioperative intraperitoneal chemotherapy regimens used with surgery at the Washington Cancer Institute.

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Area of Science:

  • Oncology
  • Surgical Oncology

Background:

  • Peritoneal surface malignancy presents challenges due to widespread implants, ascites, and potential intestinal obstruction.
  • Historically, prognosis was poor, with cure considered unattainable.
  • Recent advancements include cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (IPEC).

Purpose of the Study:

  • To review current perioperative intraperitoneal chemotherapy regimens used in conjunction with cytoreductive surgery.
  • To focus on the treatment of peritoneal surface malignancy at the Washington Cancer Institute.

Main Methods:

  • Review of various perioperative intraperitoneal chemotherapy regimens.
  • Focus on treatments administered alongside cytoreductive surgery.

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Main Results:

  • Cytoreductive surgery and perioperative intraperitoneal chemotherapy have demonstrated improved survival in select patients.
  • Multiple treatment regimens have been utilized.

Conclusions:

  • The combination of CRS and IPEC represents a significant advancement in managing peritoneal surface malignancy.
  • Further research and standardization of IPEC regimens are ongoing.