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[Idiopathic short stature: definition and treatment]

J I Diago Cabezudo1, A Carrascosa Lezcano, C J del Valle Núñez

  • 1Departamento de Investigación Clínica Lilly S.A., Madrid, Spain. diago_jesus_ignacio@lilly.com

Anales De Pediatria (Barcelona, Spain : 2003)
|April 12, 2006
PubMed

Insights

Idiopathic short stature (ISS) affects children with short height, excluding constitutional delay. Growth hormone therapy (rhGH) is effective for catch-up growth in these children.

Area of Science:

  • Pediatric Endocrinology
  • Growth Disorders

Context:

  • Short stature is a primary reason for pediatric endocrinology consultations.
  • Characterized by decreased growth velocity and short height, it encompasses various conditions.
  • Idiopathic short stature (ISS) is diagnosed when known causes are excluded in children below -2 SD height for age and sex.

Purpose:

  • To define Idiopathic Short Stature (ISS) within the differential diagnosis of short stature.
  • To highlight the potential benefit of recombinant human Growth Hormone (rhGH) therapy for ISS.

Summary:

  • ISS affects children with short stature (less than -2 SD) where other causes are ruled out.
  • Constitutional delay of growth and development is excluded from the ISS diagnosis.
  • Clinical trials confirm the efficacy of rhGH treatment for achieving catch-up growth in children with ISS.

Impact:

  • Recognizing ISS is crucial for appropriate diagnosis and management of short stature.
  • rhGH therapy offers a viable treatment option for children with ISS, promoting improved growth outcomes.
  • This understanding aids pediatric endocrinologists in identifying patients who may benefit from growth hormone intervention.

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