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Randomized controlled phase II trial of glatiramer acetate in ALS
P H Gordon1, C Doorish, J Montes
1Department of Neurology, Columbia University, NY, USA. phg8@columbia.edu
Abstract:
The authors conducted a randomized controlled trial to test the safety and immunology of glatiramer acetate in ALS. Twenty treated patients were randomly assigned to daily or biweekly injections. Ten control patients were selected from another trial and followed up concurrently. Injection reactions were the only common adverse event (p = 0.01). Treated patients showed enhanced lymphocyte proliferation (p = 0.02). The safety profile and immune effects support conducting larger trials of dose selection and efficacy.
