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Lung cancer development in primary smelter workers: a nested case-referent study
Nils-Göran Lundström1, Vagn Englyst, Lars Gerhardsson
1Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. nils-goran.lundstrom@envmed.umu.se
Objective:
The objective of this study was to study the impact of work-related exposure to mainly arsenic and lead versus smoking in primary smelter workers developing lung cancer.
Methods:
In a cohort of 3979 primary smelter workers, 46 subjects had contracted respiratory malignancies. They were compared with 141 age-matched male referents by conditional logistic regression analysis.
Results:
Cases showed a significantly higher smoking rate as compared with referents: odds ratio (OR) = 4.0; 95% confidence interval (CI) = 1.6-10.1; P = 0.003. When restricted to smokers (33 cases, 63 referents), the cumulative air arsenic exposure index, but not the lead exposure indices, was significantly higher among the cases: OR = 1.07; 95% CI = 1.02-1.11; P = 0.005.
Conclusions:
Cumulative arsenic exposure and smoking were identified as risk factors for the development of lung cancer; lead exposure, however, was not.
