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Related Experiment Videos

Activated partial thromboplastin time waveform analysis: a new tool to detect infection?

Nicolas Chopin1, Bernard Floccard, Frédéric Sobas

  • 1Service de Réanimation Chirurgicale and Laboratoire d'Hémostase, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.

Critical Care Medicine
|April 12, 2006
PubMed
Summary

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Activated partial thromboplastin time (aPTT) waveform analysis can diagnose severe sepsis and predict mortality in intensive care units. This inexpensive tool offers rapid insights for managing septic patients.

Area of Science:

  • Critical Care Medicine
  • Hematology
  • Infectious Disease

Background:

  • The activated partial thromboplastin time (aPTT) waveform can indicate a high-risk intensive care unit (ICU) population with sepsis or increased mortality.
  • Investigating the abnormal aPTT biphasic waveform as a diagnostic and prognostic marker for infection is crucial.

Purpose of the Study:

  • To evaluate the diagnostic and prognostic value of the abnormal aPTT biphasic waveform in patients with sepsis.
  • To compare the aPTT waveform analysis with procalcitonin and C-reactive protein for sepsis diagnosis.

Main Methods:

  • A prospective, observational study was conducted in a university hospital surgical ICU.
  • 187 patients meeting systemic inflammatory response syndrome criteria were analyzed.
  • aPTT waveform analysis, procalcitonin, and C-reactive protein were measured on days 1-3.

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Main Results:

  • The biphasic waveform was significantly more abnormal in severe sepsis/septic shock patients compared to sepsis/systemic inflammatory response syndrome patients.
  • aPTT waveform analysis demonstrated higher accuracy than procalcitonin and C-reactive protein in differentiating severe sepsis and septic shock.
  • The biphasic waveform showed high specificity (91%) and negative predictive value (98%) for predicting sepsis-related mortality on day 3.

Conclusions:

  • aPTT waveform analysis is an effective, inexpensive, and readily available tool in ICUs for diagnosing severe sepsis.
  • This method provides valuable information for the prognosis of septic patients.
  • The analyzer offers rapid diagnostic and prognostic insights when available.