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Yeast Signaling

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Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

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Related Experiment Video

Updated: Jul 6, 2026

Assay for Adhesion and Agar Invasion in S. cerevisiae

Assay for Adhesion and Agar Invasion in S. cerevisiae

Published on: November 8, 2006

NDR kinases regulate essential cell processes from yeast to humans.

Alexander Hergovich¹, Mario R Stegert, Debora Schmitz

¹Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

Nature Reviews. Molecular Cell Biology

|April 12, 2006

Summary

The nuclear Dbf2-related (NDR) protein-kinase family regulates key cellular functions across species. Research reveals conserved roles for NDR kinases in processes like cell division and apoptosis, emphasizing their importance.

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Assay for Adhesion and Agar Invasion in S. cerevisiae

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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

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Published on: September 26, 2025

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

The nuclear Dbf2-related (NDR) protein-kinase family plays crucial roles in cellular processes.
These processes include morphological changes, cell division, and programmed cell death.

Purpose of the Study:

To elucidate the regulatory mechanisms and functions of NDR family members.
To highlight the conserved roles of NDR kinases across different organisms.

Main Methods:

Comparative analysis of data from yeast, worms, flies, mice, and human cells.
Review of recent progress in understanding NDR kinase regulation and function.

Main Results:

NDR kinases are essential for fundamental cellular processes.
Conserved functions of NDR kinases were identified across diverse species.
Mechanisms underlying NDR kinase regulation and function have been elucidated.

Conclusions:

NDR protein-kinase family members are vital for cell cycle control and other critical cellular events.
The conserved nature of NDR kinases underscores their fundamental importance in eukaryotic biology.