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Acute erythroleukemia with t(3;5) accompanied by hepatocellular carcinoma
H Nakagawa1, S Tanaka, T Takashima
1Third Department Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
International Journal of Hematology
|June 1, 1991
Abstract:
A female patient in whom acute nonlymphocytic leukemia (ANLL, FAB-M6) developed during treatment of hepatocellular carcinoma (HCC) is described. Two years after partial hepatectomy and subsequent chemotherapy, leukemia developed following a 2 month preleukemic stage. Chromosomal analysis revealed an abnormal karyotype, 46,XX,-5, + der(5)t(3;5)(q25;q31). The balanced translocation t(3;5) has been observed in all types of ANLL and MDS except for ANLL M3 subtype. We summarize patients with ANLL M6 and t(3;5).