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Updated: Aug 9, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
[Clinical study of acute diarrhea caused by rotavirus]
Doina Mihalache1, Rodica Fîntînaru, Monica Iacob
1Universitatea de Medicină şi Farmecie Gr.T. Popa Iaşi, Facultatea de Medicină, Clinica de Boli Infecţioase.
Insights
Rotavirus is a significant cause of acute diarrhea in infants and young children, often associated with comorbidities and leading to dehydration. Early diagnosis and rehydration are crucial for recovery.
Area of Science:
- Pediatrics
- Infectious Diseases
- Virology
Context:
- Acute diarrhea is a common and serious illness in infants and children.
- Rotavirus is a known pathogen responsible for gastroenteritis worldwide.
- Understanding the prevalence and clinical implications of Rotavirus in specific populations is essential for public health.
Purpose:
- To determine the role of Rotavirus in acute diarrhea among children admitted to a hospital.
- To identify associated symptoms and risk factors in Rotavirus-infected children.
- To evaluate the clinical course and management of Rotavirus gastroenteritis.
Summary:
- A prospective study of 164 infants and children (1 month to 3 years) with acute diarrhea was conducted.
- Rotavirus was identified as the causative agent in 18.29% of cases, with higher prevalence in children with dystrophy or comorbidities.
- Commonly associated symptoms included vomiting, respiratory infections, and dehydration, necessitating rehydration therapy.
Impact:
- This study highlights Rotavirus as a key contributor to acute diarrhea in young children.
- Findings underscore the importance of considering Rotavirus in differential diagnosis, especially in vulnerable pediatric populations.
- Effective management, including prompt rehydration, is critical for favorable outcomes in Rotavirus gastroenteritis.
Abstract:
To establish the implication of Rotavirus in acute diarrhea of babies and children. Prospective study on 164 patients aged between 1 month and 3 years with acute diarrhea, admitted in the Clinical Hospital of Infectious Diseases Iaşi between 01.01.2005 - 31.03.2005. Rotavirus cause the illness in 30 patients (18.29%). The disease was more prevalent among children with dystrophy or with other comorbidities like: iron-deficiency anemia, intestinal parasitosis, rhinopharyngitis, pneumococcal meningitidis. In seven cases the infectious was considered to be nosocomial. During the illness patients also accused other symptoms, while in order of frequency were: common respiratory infection (13.3%), nausea and vomiting (40%), maculopapular eruption and intestinal pneumonia (16.6%), acute pharyngitis (10%). In this study latex agglutination confirmed the diagnosis. Vomiting and diarrhea led in all cases to moderate or severe dehydration. Appropriate rehydration was necessary but only in 12 cases was made through intravenous access with: Ringer lactate, isotonic sodium chloride solutions. Most children recovered with in 5 days.
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