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Updated: Aug 9, 2026
Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
Published on: August 30, 2017
Structural synaptic remodeling in the perirhinal cortex of adult and old rats following object-recognition visual
D Platano1, C Bertoni-Freddari, P Fattoretti
1Department of Human and General Physiology, University of Bologna, Bologna, Italy.
Abstract:
The ultrastructural features of layer II synapses in the perirhinal cortex of adult (4- to 6-month-old) and old (25- to 27-month-old) rats exposed to a six-session object recognition visual training were investigated by morphometric methods. The comparative analysis showed a higher synaptic numeric density, a lower synaptic average area, and a lower percentage of megasynapses (S > 0.5 microm2) in old trained rats versus controls, and a higher percentage of small (S < 0.15 microm2) junctions in adult trained rats versus controls. The more marked synaptic remodeling underlying memory consolidation in the perirhinal cortex of old rats might reflect a pre-existing lower dynamic status.
