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Published on: October 29, 2013
Hydrops lysosomalis generalisatus--an underestimated side effect of hydroxyethyl starch therapy?
Martin Schmidt-Hieber1, Christoph Loddenkemper, Stefan Schwartz
1Medizinische Klinik III (Hämatologie, Onkologie und Transfusionsmedizin), Charité-Campus Benjamin Franklin, Berlin, Germany. martin.schmidt-hieber@charite.de
Abstract:
Hydroxyethyl starch (HES) is usually considered to be associated with limited side effects. Generalized foamy cell macrophage syndrome after HES therapy has rarely been reported since Schaefer first described it as 'hydrops lysosomalis generalisatus' in 1982. We present a 19-yr-old male who received large amounts of HES. A bone marrow and a liver biopsy were performed because of persistent thrombocytopenia and liver dysfunction. We found severe infiltration of foamy cell degenerated macrophages in both organ systems, indicating that sequelae of HES therapy have to be included in the differential diagnosis of bone marrow and liver dysfunction.
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