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Metabolic factors associated with benign prostatic hyperplasia.
J Kellogg Parsons1, H Ballentine Carter, Alan W Partin
1Division of Urology, University of California San Diego, 200 West Arbor Drive, San Diego, California 21287, USA. k0parsons@ucsd.edu
The Journal of Clinical Endocrinology and Metabolism
|April 13, 2006
Summary
Obesity and high blood sugar levels, including diabetes, are significant risk factors for developing benign prostatic hyperplasia (BPH). These metabolic conditions are linked to prostate enlargement in men.
Area of Science:
- Urology
- Endocrinology
- Public Health
Background:
- Benign prostatic hyperplasia (BPH) is a widespread health issue with an unclear cause.
- Obesity and glucose metabolism abnormalities may influence prostate growth and contribute to BPH.
Purpose of the Study:
- To investigate the association between obesity, fasting plasma glucose, and diabetes with prostate enlargement.
- To determine if these metabolic factors are risk factors for benign prostatic hyperplasia (BPH).
Main Methods:
- Cross-sectional analysis of 422 adult men from The Baltimore Longitudinal Study of Aging.
- Prostate volume measured using pelvic magnetic resonance imaging.
- Analysis accounted for robust variance estimates for repeated measures.
Main Results:
- Severely obese men (BMI ≥ 35 kg/m²) had a significantly higher odds ratio (3.52) for prostate enlargement.
- Men with elevated fasting glucose (>110 mg/dl) showed increased odds (2.98) of an enlarged prostate.
- A diagnosis of diabetes was also associated with a higher odds ratio (2.25) for prostate enlargement.
Conclusions:
- Obesity, particularly severe obesity, is a significant risk factor for benign prostatic hyperplasia (BPH).
- Elevated fasting plasma glucose and a diagnosis of diabetes are independently associated with an increased risk of BPH.
- These findings highlight the role of metabolic health in prostate health.