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Effect of two flavonoid compounds on central nervous system. Analgesic activity
M Picq1, S L Cheav, A F Prigent
1Laboratoire de Chimie Biologique, Institut National des Sciences Appliquées de Lyon, Unité INSERM 205, Villeurbanne, France.
Abstract:
The psychopharmacological profile of quercetin (Q) and penta-O-ethylquercetin (PQ) showed for both compounds a sedative effect on central nervous system in mice. In this set of pharmacological tests (hypothermia, spontaneous motility, psychomotor activity) penta-O-ethylquercetin always exerted a more pronounced effect than quercetin, probably due to the difference of lipophilicity. In analgesia experiments such as acetic acid-induced writhings, penta-O-ethylquercetin showed a significant dose-related effect whereas quercetin was inactive. As pretreatment with naloxone failed to antagonize the analgesic activity of penta-O-ethylquercetin, it was suggested that penta-O-ethylquercetin acted mainly peripherally.