Related Experiment Video
Updated: Aug 9, 2026

Standardized Methods for Measuring Induction of the Heat Shock Response in Caenorhabditis elegans
Published on: July 3, 2020
Pharmacological modulation of the heat shock response
1Department of Medical Chemistry, Semmelweis University, Budapest, Hungary.
Abstract:
Life presents a continuous series of stresses. Increasing the adaptation capacity of the organism is a long-term survival factor of various organisms and has become an attractive field of intensive therapeutic research. Induction of the heat shock response promotes survival after a wide variety of environmental stresses. Preclinical studies have proven that physiological and pharmacological chaperone inducers and co-inducers are an efficient therapeutic approach in different acute and chronic diseases. In this chapter, we summarize current knowledge of the current state of chaperone modulation and give a comprehensive list of the main drug candidates.
Related Concept Videos
Other Stress Responses in Bacteria
Regulation of the Unfolded Protein Response
Bacterial Protein Maturation
Pharmacodynamic Models: Direct Effect Model and Indirect Response Model
Stringent Response in E. coli
Molecular Chaperones and Protein Folding
The...

