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Related Experiment Videos

Our favourite alternative splice site.

Hubert Lerivray1, Agnès Méreau, H Beverley Osborne

  • 1UMR 6061 Génétique et Développement, CNRS/Université de Rennes 1, IFR 140 Génétique Fonctionnelle, Agronomie et Santé, Faculté de Médecine CS 34317, Rennes, France. hubert.lerivray@univ-rennes1.fr

Biology of the Cell
|April 14, 2006
PubMed
Summary

Alternative splicing generates diverse messenger RNAs (mRNAs) from single genes. Researchers found the Friendly Alternative Splicing and Transcripts DataBase (FAST DB) to be a preferred resource for studying these genetic variations.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Alternative splicing is a key biological process in mammals, generating transcriptomic diversity from a single gene.
  • Aberrant alternative splicing patterns are linked to various diseases, including cancers and genetic disorders.
  • The complexity of alternative splicing necessitates accessible data repositories for researchers.

Purpose of the Study:

  • To compare existing web resources for accessing information on alternatively spliced genes.
  • To identify a user-friendly and comprehensive database for alternative splicing data.

Main Methods:

  • Comparative analysis of web-based resources.
  • Evaluation of data accessibility and usability for biological and medical researchers.

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Main Results:

  • The Friendly Alternative Splicing and Transcripts DataBase (FAST DB) was identified as a superior resource.
  • FAST DB offers advantages in accessing information on alternatively spliced genes.

Conclusions:

  • Accessible and specialized databases are crucial for advancing research in alternative splicing.
  • FAST DB is recommended for researchers studying alternative splicing and its role in health and disease.