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Updated: Aug 9, 2026

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
Synthetic diether-linked cationic lipids for gene delivery
Dongliang Liu1, Weihong Qiao, Zongshi Li
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Zhongshan Road 158th, Dalian, 116012, China. dut_liud@yahoo.com.cn
Abstract:
Quaternary ammonium lipids 2a-p, with diether linkages between hydrocarbon chains and their ammonium headgroups, were synthesized as potential vectors for cationic liposome-mediated gene delivery. Varying the length of carbon chains and quaternary ammonium heads as well as different anionic complexes will enable the study of the structure-function relationships of these cationic lipids in terms of gene delivery properties.
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