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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Chronic kidney disease and risk of incident myocardial infarction and all-cause and cardiovascular disease mortality
Christa Meisinger1, Angela Döring, Hannelore Löwel
1Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Stenglinstr. 2, D-86156 Augsburg, Germany. christa.meisinger@gsf.de
European Heart Journal
|April 14, 2006
Summary
Chronic kidney disease (CKD) significantly increases the risk of heart attacks and cardiovascular death in both men and women. However, CKD was not found to be a risk factor for all-cause mortality in this population-based study.
Area of Science:
- Cardiology
- Nephrology
- Epidemiology
Background:
- Chronic kidney disease (CKD) is an established risk factor for mortality and cardiovascular disease (CVD) events in high-risk groups.
- Data from population-based studies on the association between CKD and adverse outcomes are limited and show inconsistencies.
- Investigating gender-specific risks associated with CKD in the general population is crucial.
Purpose of the Study:
- To examine the gender-specific association between CKD and all-cause mortality.
- To assess the link between CKD and cardiovascular mortality.
- To determine the relationship between CKD and incident myocardial infarction (MI) in a population-based cohort.
Main Methods:
- Utilized data from 7534 individuals (3860 men, 3674 women) aged 45-74 from MONICA Augsburg surveys (1984-1995).
- Defined CKD based on estimated glomerular filtration rate (eGFR) between 15-59 mL/min/1.73 m².
- Employed Cox proportional hazard models to estimate Hazard Ratios (HRs) for mortality and incident MI, with follow-up until December 31, 2002.
Main Results:
- In women, CKD was significantly associated with increased risk of incident MI (HR 1.67; 95% CI 1.07-2.61) and CVD mortality (HR 1.60; 95% CI 1.17-2.18).
- In men, CKD showed significant associations with incident MI (HR 1.51; 95% CI 1.09-2.10) and CVD mortality (HR 1.48; 95% CI 1.15-1.92) after adjusting for CVD risk factors.
- No significant association was found between CKD and all-cause mortality in either men or women.
Conclusions:
- CKD is strongly linked to a higher risk of myocardial infarction and cardiovascular death in the general population.
- These associations persist independently of common cardiovascular risk factors in both genders.
- CKD poses a significant cardiovascular risk that warrants clinical attention in primary care settings.
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