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Related Experiment Video

Updated: Jan 9, 2026

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Uric acid and inflammatory markers.

Carmelinda Ruggiero1, Antonio Cherubini, Alessandro Ble

  • 1Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, MD, USA. ruggieroc@grc.nih.gov

European Heart Journal
|April 14, 2006
PubMed
Summary
This summary is machine-generated.

High uric acid (UA) levels are linked to increased inflammation in older adults, even within normal ranges. This association persists after adjusting for other health factors, suggesting UA may play a role in inflammatory processes.

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Area of Science:

  • Cardiovascular Research
  • Inflammation Biology
  • Gerontology

Background:

  • The role of uric acid (UA) in atherosclerosis and atherothrombosis remains controversial.
  • Epidemiological studies suggest UA may be a cardiovascular disease risk factor and a negative prognostic marker in heart failure.
  • This study investigates the relationship between UA and inflammatory markers in an older population.

Purpose of the Study:

  • To evaluate the association between plasma uric acid levels and various inflammatory markers.
  • To determine if this association holds true even within the normal range of uric acid.
  • To explore the role of UA in inflammation in a population-based sample of older adults.

Main Methods:

  • Analysis of plasma uric acid and inflammatory markers (WBC, neutrophils, CRP, IL-1ra, IL-6, sIL-6r, IL-18, TNF-alpha) in 957 Italian subjects aged 65-95.
  • Collection of data on potential confounders (age, sex, lifestyle, diseases).
  • Statistical analysis to assess associations, including adjustments for confounders and analysis of subgroups with normal UA levels.

Main Results:

  • Significantly higher levels of WBC, neutrophils, C-reactive protein, IL-1ra, IL-6, sIL-6r, IL-18, and TNF-alpha were observed across increasing UA quintiles.
  • These associations remained significant after adjusting for confounders.
  • In participants with normal UA levels, UA was independently associated with neutrophils, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha.

Conclusions:

  • A significant positive association exists between uric acid levels and multiple inflammatory markers in older adults.
  • This association is evident in the general population sample and in those with normal UA levels.
  • The prevalence of elevated C-reactive protein and IL-6 significantly increases with higher UA quintiles.