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Related Experiment Videos

Intracranial time-resolved contrast-enhanced MR angiography at 3T.

T A Cashen1, J C Carr, W Shin

  • 1Department of Biomedical Engineering, Northwestern University, Feinberg School of Medicine of Northwestern University, Chicago, IL, USA.

AJNR. American Journal of Neuroradiology
|April 14, 2006
PubMed
Summary

High-field (3T) MRI enables faster imaging for diagnosing cerebrovascular disorders. This advanced MR angiography (MRA) technique provides high temporal resolution for evaluating arteriovenous shunting and retrograde flow.

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Area of Science:

  • Radiology
  • Medical Imaging
  • Neuroimaging

Background:

  • Conventional digital subtraction angiography is used for evaluating cerebrovascular disorders with arteriovenous shunting or retrograde flow.
  • Multiphase MR angiography (MRA) offers a noninvasive alternative but faces challenges in balancing signal-to-noise ratio (S/N), spatial, and temporal resolution.

Purpose of the Study:

  • To present a method for high-temporal-resolution MRA using undersampling strategies and a 3T scanner.
  • To enable noninvasive assessment of cerebrovascular disorders with arteriovenous shunting or retrograde flow.

Main Methods:

  • Numerical simulations optimized imaging parameters at 3T for S/N and acquisition rate within SAR limits.
  • An imaging protocol was developed using partial Fourier imaging, parallel imaging, and time-resolved echo-shared acquisition technique (TREAT) for sufficient undersampling.

Related Experiment Videos

  • Increased S/N at 3T was verified in vivo.

    • Main Results:

    • Intracranial time-resolved contrast-enhanced MRA at 3T with high acceleration yielded diagnostic images in volunteers and patients.
    • The technique achieved a spatial resolution of 1.1 x 1.1 x 2.5 mm and temporal resolution of 2.5 seconds/frame.
    • Combining multiple modest acceleration methods resulted in high overall acceleration with minimal artifacts.

    Conclusions:

    • High-field (3T) magnets enhance S/N, which can be translated to higher temporal resolution via acceleration strategies.
    • Intracranial time-resolved MRA is feasible, offering a noninvasive diagnostic tool for cerebrovascular pathologies.