Linezolid and human polymorphonuclear leukocyte function
Related Experiment Video
Updated: Aug 9, 2026

Measuring Granulocyte and Monocyte Phagocytosis and Oxidative Burst Activity in Human Blood
Published on: September 12, 2016
Are Naess1, Kristin Stenhaug Kilhus, Tone W Nystad
1Institute of Medicine, University of Bergen, Norway. are.nass@med.uib.no
Background:
To examine whether linezolid, a new oxazolidinone antibiotic, has an effect on human polymorphonuclear leukocyte (PMN) function.
Methods:
Flow-cytometric techniques for the demonstration of PMN chemotaxis towards zymosan-activated serum, and phagocytosis and respiratory burst after incubation in linezolid.
Results:
Linezolid at concentrations of 10- 160 mg/l did not significantly influence PMN function as measured by chemotaxis, phagocytosis and respiratory burst.
Conclusions:
Linezolid at therapeutic or supratherapeutic concentrations does not influence human PMN function. This applies to the chemically pure substance as well as to the commercial preparation containing additives for intravenous infusion.
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