Related Experiment Video
Updated: Aug 9, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Analysis of co-aggregation of cancer based on registry data
Abigail G Matthews1, Rebecca A Betensky, Hoda Anton-Culver
1Massachusetts General Hospital Biostatistics Center, Boston, MA 02114, USA.
Objective:
An exploratory analysis of co-aggregation of cancers using registry-based data.
Methods:
We utilized sibships from over 18,000 families who had been recruited to the NCI-sponsored multi-institutional Cancer Genetics Network. The analysis assesses co-aggregation at the individual and family level and adjusts for ascertainment.
Results:
We found statistically significant familial co-aggregation of lung cancer with pancreatic (adjusted p < 0.001), prostate (adjusted p < 0.003), and colorectal cancers (adjusted p = 0.004). In addition, we found significant familial co-aggregation of pancreatic and colorectal cancers (adjusted p = 0.018), and co-aggregation of hematopoietic and (non-ovarian) gynecologic cancers (adjusted p = 0.01).
Conclusion:
This analysis identified familial aggregation of cancers for which a genetic component has yet to be established.
Related Concept Videos
Cancer Survival Analysis
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Prevention
Some...
Cancer Prevention
Some...
Comparing the Survival Analysis of Two or More Groups
