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Updated: Aug 9, 2026

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens
06:02

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens

Published on: April 18, 2013

Prevention of contrast-induced nephropathy with volume supplementation

C Mueller1

  • 1Department of Internal Medicine, University Hospital, Basel, Switzerland. chmueller@uhbs.ch

Kidney International. Supplement
|April 14, 2006
PubMed

Insights

Intravenous and oral fluid hydration effectively prevents contrast-induced nephropathy (CIN) in most patients. Optimal protocols involve saline infusion before and after procedures, alongside encouraging oral fluid intake for CIN prevention.

Area of Science:

  • Nephrology
  • Radiology
  • Cardiology

Background:

  • Contrast-induced nephropathy (CIN) is a significant risk following radiocontrast procedures.
  • Volume supplementation is the primary strategy for CIN prevention.
  • Current evidence supports combined intravenous and oral hydration for low- to moderate-risk patients.

Purpose of the Study:

  • To review current evidence on volume supplementation for CIN prevention.
  • To outline optimal hydration protocols for CIN prevention.
  • To identify areas for future research in CIN prevention strategies.

Main Methods:

  • Review of existing literature on volume supplementation and CIN.
  • Analysis of current guidelines and expert recommendations.
  • Discussion of intravenous and oral hydration strategies.

Main Results:

  • Combined intravenous (0.9% saline at 1 ml/kg/h for 24h) and oral fluid intake is effective for CIN prevention in low- to moderate-risk patients.
  • Bicarbonate infusion may permit shorter hydration periods.
  • Outpatient protocols combining IV and oral hydration are under investigation.

Conclusions:

  • Volume supplementation is crucial for preventing CIN.
  • Standardized hydration protocols are essential for patient care.
  • Further research is needed to optimize volume supplementation strategies for CIN prevention.

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