Beta2-microglobulin, a uremic toxin with a double meaning
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Updated: Aug 9, 2026

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
Published on: March 4, 2022
B Canaud1, M Morena, J P Cristol
1Nephrology, Dialysis and Intensive Care Unit, Lapeyronie University Hospital, Montpellier, France. b-canaud@chu-montpellier.fr
Abstract:
beta(2)M is a strong and independent indicator of hemodialysis patient outcomes and an excellent surrogate for middle molecules, and deserves to be routinely monitored and incorporated into dialysis adequacy targets. beta(2)M has a double meaning, reflecting both dialysis efficacy in terms of solute mass transfer and patient bioactivity. The work of Ward et al. in this issue warrants a study to test the hypothesis that long daily hemodiafiltration treatment would be the optimal renal replacement modality to improve dialysis patient outcomes.
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