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Related Experiment Videos

[Fever--useful or noxious symptom that should be treated?].

A Schaffner1

  • 1Universitätsspital Zürich, Labor für Makrophagenbiologie.

Therapeutische Umschau. Revue Therapeutique
|April 15, 2006
PubMed
Summary
This summary is machine-generated.

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Severe hypothermia in a patient with cerebral relapse of Whipple's disease.

Infection·2004

Fever management with antipyretics offers limited benefit for most infections, particularly severe ones. Symptomatic relief is appropriate for low-risk infections when patients experience fever and discomfort.

Area of Science:

  • Evolutionary Biology
  • Immunology
  • Pharmacology

Background:

  • Fever is an ancient host defense mechanism conserved through evolution.
  • Both poikilothermic and endothermic organisms utilize fever for host defense.
  • Despite its evolutionary advantage, fever is commonly treated with antipyretics.

Purpose of the Study:

  • To evaluate the role and efficacy of antipyretic therapy in various clinical settings.
  • To assess the benefits and risks of fever management in different patient populations.
  • To provide evidence-based recommendations for antipyretic use.

Main Methods:

  • Review of existing studies on fever and antipyretic use.
  • Analysis of clinical trials, including those in intensive care settings and specific patient groups.

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  • Consideration of experimental findings in rodents versus human clinical observations.

    • Main Results:

    • Antipyretic therapy has a marginal role in recovery from low-risk infections.
    • A large study on ibuprofen in severe sepsis showed no clear benefit or harm.
    • Non-steroidal antirheumatics (NSAR) improve well-being in influenza-like illnesses with minimal side effects.
    • Antipyretic use is not established as beneficial in special patient groups (e.g., brain injury, cardiac failure).
    • Fever reduction does not decrease recurrence in children with a history of febrile convulsions.
    • Antipyretics may be advisable for fever in stroke patients, despite a lack of proven benefit.

    Conclusions:

    • Symptomatic antipyretic therapy is appropriate for low-risk infections if fever causes suffering.
    • For severe infections, antipyretic therapy can be used individually, with caution regarding outcome.
    • The evolutionary advantage of fever suggests a nuanced approach to its management.