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Related Experiment Videos

Cholesterol crystals causing falsely elevated automated cell count.

Peter U F Shen1, Judy L Blair

  • 1Department of Pathology & Laboratory Medicine, Eastern Colorado (Denver) Veterans Administration Medical Center, Denver 80220, USA.

American Journal of Clinical Pathology
|April 15, 2006
PubMed
Summary
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Cholesterol crystals in body fluid can falsely elevate automated cell counts, mimicking high white blood cell (WBC) and red blood cell (RBC) levels. Microscopic review is crucial for accurate diagnosis.

Area of Science:

  • Clinical Chemistry
  • Hematology
  • Pathology

Background:

  • Automated cell counters are essential for body fluid analysis.
  • Accurate cell counts are critical for diagnosing various medical conditions.

Observation:

  • Three cases presented with body fluid containing numerous cholesterol crystals.
  • These crystals led to falsely elevated white blood cell (WBC) and red blood cell (RBC) counts on automated analyzers.

Findings:

  • Microscopic examination confirmed abundant cholesterol crystals in all samples.
  • Automated cell counts significantly overestimated manual counts due to crystal interference.
  • The study discusses the pathophysiology of cholesterol crystal formation in effusions.

Implications:

Related Experiment Videos

  • Highlights the potential for analytical interference by cholesterol crystals in automated body fluid analysis.
  • Underscores the importance of microscopic correlation to prevent misdiagnosis.
  • Reviews chylous and pseudochylous effusions and the role of automated instruments.