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Updated: Aug 9, 2026
Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
[Bacterial pathogens and resistance patterns in community acquired pediatric urinary tract infection: experience of
Shu-Ying Fan1, Bi-Li Zhang, Wen-Hong Wang
1Department of Nephrology, Children's Hospital of Tianjin, Tianjin 300074, China. lihua1588@sohu.com
Insights
Escherichia coli (E. coli) is the primary cause of childhood urinary tract infections. Antibiotic selection for pediatric urinary tract infections should be guided by drug sensitivity testing due to varying resistance patterns.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Microbiology
- Antimicrobial Resistance
Context:
- Community-acquired urinary tract infections (UTIs) are common in children.
- Understanding pathogen distribution and antimicrobial susceptibility is crucial for effective treatment.
- Retrospective analysis of 152 pediatric UTI cases (December 2001-December 2004).
Purpose:
- To determine the prevalent pathogens causing childhood UTIs.
- To analyze antimicrobial resistance patterns of these pathogens.
- To inform optimal antibiotic prescribing for pediatric UTIs.
Summary:
- Gram-negative bacilli, particularly Escherichia coli (E. coli) (56.2%), were the predominant pathogens.
- Enterococcus faecalis (15.1%) emerged as another significant pathogen.
- E. coli exhibited high resistance to common antibiotics but low resistance to third-generation cephalosporins, nitrofurantoin, aztreonam, and amikacin.
Impact:
- Highlights E. coli as the leading cause of pediatric UTIs.
- Identifies Enterococcus as an increasingly important pathogen.
- Emphasizes the necessity of drug-sensitivity testing for guiding antibiotic therapy in pediatric UTIs.
Objective:
This study investigated the pathogen distribution and resistance patterns in childhood urinary tract infection in order to provide references for optimal use of antibiotics in the treatment of this disorder.
Methods:
The clinical data of 152 children with community acquired urinary tract infection (urinary culture positive) between December 2001 and December 2004 were studied retrospectively. The bacterial pathogens of urinary tract infection and antimicrobial resistance were analyzed.
Results:
Gram-negative bacilli was predominant pathogenic bacteria, accounting for 79.0% of the cases, and Escherichia coli (E. coli) was most commonly found (56.2%). Gram-positive cocci accounted for 18.4%, including 15.1% of Enterococcus faecalis. Fungi was rarely seen, accounting for only 2.6%. E. coli had a resistance rate of more than 50% to ampicillin, amoxicillin/clavulate, co-trimoxazole, cefradine, and fosomycin, but a very low resistance rate (< 4%) to 3rd generation cefalosporin, nitrofurantoi, azactom and amikacin. Enterococcus faecalis had a low resistance rate (< 20%) to ampicillin, vancomycin, penicillin, and nitrofurantoin.
Conclusions:
E. coli is the major pathogen in community acquired pediatric urinary tract infection, and Enterococcus has been become another important pathogen. Selection of antibiotics for the treatment of this disorder should base on drug-sensitive test results.
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