Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IgA antibodies in Rett syndrome.

K L Reichelt1, O Skjeldal

  • 1Institute of Pediatric Research, The National Hospital, University of Oslo, N-0027 Oslo, Norway. K.L.Reichelt@lkinmed.uio.no

Autism : the International Journal of Research and Practice
|April 15, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary Intervention for a Seven Year Old Girl with Autistic Behaviour.

Nutritional neuroscience·2016
Same author

The possibility and probability of a gut-to-brain connection in autism.

Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists·2009
Same author

Urinary peptide levels in women with eating disorders. A pilot study.

Eating and weight disorders : EWD·2003
Same author

Mutation analysis in the MECP2 gene and genetic counselling for Rett syndrome.

Journal of medical genetics·2003
Same author

Can the pathophysiology of autism be explained by the nature of the discovered urine peptides?

Nutritional neuroscience·2003
Same author

A serotonin uptake-stimulating tetra-peptide found in urines from ADHD children.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2003

Girls with Rett syndrome show significantly higher IgA and IgG antibody levels to gluten, gliadin, and casein. This suggests a potential increase in protein absorption from the gut in individuals with Rett syndrome.

Area of Science:

  • Immunology
  • Neurodevelopmental Disorders
  • Gastroenterology

Background:

  • Rett syndrome is a rare neurodevelopmental disorder primarily affecting girls.
  • Altered immune responses and gastrointestinal issues are sometimes reported in Rett syndrome.
  • Antibody levels can indicate immune system activity and protein interactions.

Purpose of the Study:

  • To investigate antibody levels to common dietary proteins in girls with Rett syndrome.
  • To compare these levels with those in a healthy control group.
  • To explore potential links between antibody responses and gastrointestinal function.

Main Methods:

  • Quantified immunoglobulin A (IgA) and immunoglobulin G (IgG) antibody levels.
  • Tested antibodies against gluten, gliadin, and casein.

Related Experiment Videos

  • Compared levels between 23 girls with Rett syndrome and 53 controls.

    • Main Results:

    • Statistically significant increases in IgA and IgG antibodies to gluten, gliadin, and casein were observed in the Rett syndrome group.
    • Elevated antibody levels were highly significant when compared to the control group.
    • The underlying cause for these elevated levels remains undetermined.

    Conclusions:

    • Girls with Rett syndrome exhibit heightened antibody responses to gluten, gliadin, and casein.
    • Increased IgA antibodies may suggest enhanced protein or epitope uptake from the gut.
    • Further research is needed to elucidate the mechanisms and implications of these findings.