Related Experiment Video
Updated: Jul 31, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
IgA antibodies in Rett syndrome
1Institute of Pediatric Research, The National Hospital, University of Oslo, N-0027 Oslo, Norway. K.L.Reichelt@lkinmed.uio.no
Autism : the International Journal of Research and Practice
|April 15, 2006
Summary
Girls with Rett syndrome show significantly higher IgA and IgG antibody levels to gluten, gliadin, and casein. This suggests a potential increase in protein absorption from the gut in individuals with Rett syndrome.
Area of Science:
- Immunology
- Neurodevelopmental Disorders
- Gastroenterology
Background:
- Rett syndrome is a rare neurodevelopmental disorder primarily affecting girls.
- Altered immune responses and gastrointestinal issues are sometimes reported in Rett syndrome.
- Antibody levels can indicate immune system activity and protein interactions.
Purpose of the Study:
- To investigate antibody levels to common dietary proteins in girls with Rett syndrome.
- To compare these levels with those in a healthy control group.
- To explore potential links between antibody responses and gastrointestinal function.
Main Methods:
- Quantified immunoglobulin A (IgA) and immunoglobulin G (IgG) antibody levels.
- Tested antibodies against gluten, gliadin, and casein.
- Compared levels between 23 girls with Rett syndrome and 53 controls.
Main Results:
- Statistically significant increases in IgA and IgG antibodies to gluten, gliadin, and casein were observed in the Rett syndrome group.
- Elevated antibody levels were highly significant when compared to the control group.
- The underlying cause for these elevated levels remains undetermined.
Conclusions:
- Girls with Rett syndrome exhibit heightened antibody responses to gluten, gliadin, and casein.
- Increased IgA antibodies may suggest enhanced protein or epitope uptake from the gut.
- Further research is needed to elucidate the mechanisms and implications of these findings.
Related Concept Videos
01:21Smooth Endoplasmic Reticulum
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
01:29Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...