Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The continuing challenges of leprosy.

D M Scollard1, L B Adams, T P Gillis

  • 1Laboratory Research Branch, National Hansen's Disease Programs, LSU-SVM, Skip Bertman Dr., Baton Rouge, LA 70803, USA. dscoll1@lsu.edu

Clinical Microbiology Reviews
|April 15, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat.

Endocrinology·2003
Same author

Fees for RCVS members retired ... and new.

The Veterinary record·2003
Same author

Use of punctal occlusion in the treatment of canine keratoconjunctivitis sicca.

The Journal of small animal practice·2002
Same author

Clinical pathology accreditation: standards for the medical laboratory.

Journal of clinical pathology·2002
Same author

Direct NO group transfer from S-nitrosothiols to iron centres.

Chemical communications (Cambridge, England)·2002
Same author

Scavenger receptor class B type I affects cholesterol homeostasis by magnifying cholesterol flux between cells and HDL.

Journal of lipid research·2001

Leprosy involves a chronic mycobacterial infection and nerve damage. Despite being curable, this global health issue, caused by Mycobacterium leprae, remains poorly understood and challenging to combat.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Genetics
  • Microbiology

Background:

  • Leprosy is a complex disease comprising a chronic mycobacterial infection and peripheral neuropathy.
  • Mycobacterium leprae (M. leprae) infection triggers diverse human cellular immune responses.
  • Despite being curable, leprosy remains a significant global health problem, particularly in developing nations.

Purpose of the Study:

  • To review recent advancements in understanding M. leprae and host responses.
  • To highlight progress in molecular identification, genomics, and host-pathogen interactions.
  • To discuss developments in experimental models and clinical studies.

Main Methods:

  • Focus on molecular identification, genome, transcriptome, and proteome of M. leprae.

Related Experiment Videos

  • Analysis of microbial resistance mechanisms and strain recognition.
  • Utilizing gene knockout mice and armadillo models for experimental studies.
  • Reviewing clinical studies on immunology, immunopathology, genetics, nerve injury, and chemotherapy.

    • Main Results:

    • Recent advances in molecular identification and understanding of M. leprae's genetic makeup.
    • Progress in experimental models, including gene knockout mice and armadillo studies.
    • Notable developments in clinical research concerning leprosy immunology, genetics, and treatment.

    Conclusions:

    • Significant progress has been made in various aspects of leprosy research.
    • However, understanding of leprosy lags behind other major bacterial diseases.
    • Further research is crucial to address the persistent challenges posed by M. leprae.