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Published on: April 18, 2019
Synergy of arbekacin-based combinations against vancomycin hetero-intermediate Staphylococcus aureus
Ji Young Lee1, Won Sup Oh, Kwan Soo Ko
1Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, Korea.
Abstract:
This study was undertaken to evaluate the in vitro activities of arbekacin-based combination regimens against vancomycin hetero-intermediate Staphylococcus aureus (hetero-VISA). Combinations of arbekacin with vancomycin, rifampin, ampicillin-sulbactam, teicoplanin, or quinupristin-dalfopristin against seven hetero-VISA strains and two methicillin-resistant S. aureus strains were evaluated by the time-kill assay. The combinations of arbekacin with vancomycin, teicoplanin, or ampicillin-sulbactam showed the synergistic interaction against hetero-VISA strains. Data suggest that these arbekacin-based combination regimens may be useful candidates for treatment options of hetero-VISA infections.
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