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Management of HCV infection and liver transplantation

Thomas D Schiano1, Paul Martin

  • 1Adult Liver Transplantation, Recanati/Miller Transplantation Institute, Division of Liver Diseases, Department of Medicine, The Mount Sinai School of Medicine, New York, NY, USA. thomas.schiano@mountsinai.org

International Journal of Medical Sciences
|April 15, 2006
PubMed

Insights

Hepatitis C virus recurrence post-liver transplant diminishes survival. While no definitive prevention exists, managing recurrent hepatitis C infection is crucial for graft survival.

Area of Science:

  • Hepatology
  • Transplantation Immunology
  • Infectious Diseases

Background:

  • Recurrence of hepatitis C virus (HCV) infection is a significant complication after liver transplantation.
  • Post-transplant HCV recurrence negatively impacts graft and patient survival.
  • Current strategies for managing recurrent HCV are limited by patient tolerance and immunosuppression management.

Purpose of the Study:

  • To review the challenges and current approaches to managing recurrent hepatitis C virus infection in liver transplant recipients.
  • To highlight the importance of sustained viral responses in mitigating the impact of HCV recurrence on liver grafts.

Main Methods:

  • Review of existing literature on hepatitis C virus recurrence after liver transplantation.
  • Analysis of predictors for severe recurrence.
  • Discussion of treatment challenges and strategies for managing HCV in transplant patients.

Main Results:

  • Hepatitis C virus recurrence remains a frequent cause of graft loss in liver transplant recipients.
  • Predictors of severe recurrence have been identified, but no definitive preventive strategy exists.
  • Achieving sustained viral responses can reduce the negative impact of recurrent HCV on the graft.

Conclusions:

  • Recurrent hepatitis C virus infection poses a major challenge in liver transplantation, impacting long-term outcomes.
  • Effective management strategies are needed to improve patient and graft survival.
  • Hepatitis C virus infection will likely remain the most common recurrent disease in liver transplant programs.

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